Stem cells translational medicine impact factor if 201920182017. Citescore values are based on citation counts in a given year e. Stem cell therapy is an emerging alternative therapeutic or diseasemodifying strategy for amyotrophic lateral sclerosis als. In recent years, stem cell therapy has become a very promising and advanced scientific research topic. In their findings, published in the journal stem cells translational medicine, the researchers began by working with a chemotherapy drug called cisplatin, which is used against a broad range of cancers but is also known to cause damage to kidneys in around one third of all patients. Recent current research in translational medicine articles. In recent years, the progress of research on cytokinemodulated tumor microenvironment and breast cancer stem cells bcscs has shed light on. Stem cell research is dedicated to publishing highquality manuscripts focusing on the biology and applications of stem cell research. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury aki.
The root canal was successfully filled with regenerated pulp including nerves and vasculature by day 14, followed by new dentin formation along the. Stem cell biology represents a challenging research area with a huge potential translational approach. Several different types of cells have been explored, each with their own benefits and limitations. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and. Regenerative medicine is a great one with an impact factor of 3. Stem cells and development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. Reprogramming and tissue engineering, 1920 november 2015. These cells can then be genetically modified to produce. Authors will receive an email notification with instructions for downloading. Stem cells translational medicine wiley online library. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells mscs, either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic capacity to.
Recent current research in translational medicine articles recently published articles from current research in translational medicine. To date, the mainstay treatment of pancreatic cancer is a. Adult stem cells from a variety of organs can be expanded longterm in vitro as threedimensional organotypic structures termed organoids. Glioblastoma stemlike cells gscs are hypothesized to contribute to self renewal and therapeutic resistance in glioblastoma multiforme gbm tumors. With a focus on stem cells of all tissue types and their potential therapeutic applications, the journal provides clinical, basic, and translational scientists with cuttingedge research and findings. Aug 22, 2015 stem cells are often used as drugs in investigatorinitiated protocols, and so investigators need to be aware of these regulatory pathways from the earliest stage of the translational process. Press releases from alphamed press stem cells portal. Journal citation reports clarivate analytics, 2019 5year impact factor. Stem cell investigation is indexed in pubmedpmc since april, 2016. Stem cells international publishes papers in all areas of stem cell biology and applications. Some studies have demonstrated that mscs are able to. Stem cells translational medicine impact factor, if, number of article, detailed information and journal factor.
Functional differences between placental micro and. The development of treatment methods has evoked great expectations. The journal covers all aspects of stem cells embryonic stem cellsinduced pluripotent. However, this potential has remained largely unrealized owing to. There is also stem cells and development, which has published an increasing stream of very cool, higher impact stuff. Embryonal carcinoma, as do all human pluripotent stem cells, expresses tra160 and tra181 antigens, and although their molecular identities are unknown, they are commonly used as markers of. With a focus on stem cells of all tissue types and their potential therapeutic applications, the journal provides clinical, basic, and translational scientists with cuttingedge research. Application of droplet digital pcr for the detection of. Stem cells impact factor, if, number of article, detailed information and journal factor. Our readers can download the stem cells translational medicine app and. Wjsc accepts both solicited and unsolicited manuscripts. Furthermore, the nature of cells as drugs is more complex, and the translational pathway to development will require special considerations. Stem cells translational medicine works to advance the utilization of cells for clinical therapy. They also examine how defects in these posttranscriptional mechanisms deregulate tissuespecific stem cells and progenitors in human disease and stress conditions and discuss their potential as both diagnostic and therapeutic targets.
Tolerability of high dose chemotherapy and autologous stem cell transplantation in elderly patients with multiple myeloma. Submissions to stem cell research, may cover all aspects of stem cells, including embryonic stem cells, tissuespecific stem cells, cancer stem cells, developmental studies, genomics and translational research. Overexpression of a panel of cancer stem cell markers. Stem cell technologies, especially patientspecific, induced stem cell pluripotency and directed differentiation, hold great promise for changing the landscape of medical therapies. Stem cells translational medicine wolters kluwer ovid.
These cells can then be genetically modified to produce high levels of a clotting protein that was. Stem cells translational medicine works to advance the utilization of cells for clinical. Advances and challenges in immunotherapy for solid organ. Download templates and learn how to submit lab resource articles.
In december of 2014, the genetics policy institute, producer of the annual world stem cell summit, and the regenerative medicine foundation, producer of the regenerative medicine forum, agreed to merge to leverage their resources in the advancement of stem cell research, regenerative medicine, and other advanced technologies targeting cures. Improved therapeutics of modified mesenchymal stem cells. Chief editor, professor li, has a background in cardiac stem cell transplantation, using young stem. Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. Journal of regenerative medicine high impact factor journal. Articles from stem cells translational medicine are provided here courtesy of wiley. Impact of mesenchymal stem cells secretome on glioblastoma. Cirm is partnering with stem cells translational medicine to launch the proceedings of the california stem cell agency, a monthly series of commentaries, articles, interviews, webinars, forums. These adult stem cellderived organoids retain their organ identity and remain genetically stable over long periods of time. Mar 25, 2015 although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. To profile their molecular influence on recipient hearts, systems proteomics was here applied in a. Stem cells translational medicine works to advance the utilization of cells for.
Boost for poor graft function after allogeneic hematopoietic stem cell transplantation. Pancreatic cancer is one of the most challenging cancers among gastrointestinal malignancies due to various factors including aggressive molecular behavior driven by the loss of multiple tumor suppressor genes 1, 2, lack of effective immune response with low immunogenicity and complex tumor microenvironment. Mesenchymal stem cells mscs have shown promising regenerative effects in experimental aki models, but the specific mechanism is still unclear. Cardiopoietic stem cell therapy restores infarctionaltered. Stem cells translational medicine sctm is dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. The potential for the clinical application of stem cells in tissue regeneration is clearly significant. Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Alterations in the development of the placental vasculature can lead to pregnancy complications, such as preeclampsia.
New frontiers in stem cell research and translational. Table of contents page 33 stem cells international hindawi. Induced pluripotent stem cells possess an embryoniclike state and therefore have a high proliferative capacity, but they also pose a risk of teratoma formation. Mesenchymal stem cells msc have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune. Apr 12, 2018 in their findings, published in the journal stem cells translational medicine, the researchers began by working with a chemotherapy drug called cisplatin, which is used against a broad range of cancers but is also known to cause damage to kidneys in around one third of all patients. Updated list of high journal impact factor regenerative. Current research in translational medicine journal elsevier. Phase i trial of repeated intrathecal autologous bone marrow. Articles published in wjsc are highquality, basic and clinical, influential research articles by established academic authors as well as new researchers. This study aims to examine the predictive value of cancer stem cell csc markers on the progression and recurrence of cca patients. Stem cells are often used as drugs in investigatorinitiated protocols, and so investigators need to be aware of these regulatory pathways from the earliest stage of the translational process. Table of contents page 64 stem cells international hindawi. Advances and challenges in immunotherapy for solid organ and.
Stem cell journals regenerative biology research lab. Therapeutic use of stem cells for cardiovascular disease. Stem cells translational medicine information for authors. Glioblastoma gbm is a highly aggressive primary brain cancer, for which curative therapies are not available. The microenvironment of pancreatic cancer carries unique features with increased desmoplastic reaction and is infiltrated by regulatory t cells and myeloidderived suppressor. Stem cells translational medicine impact factor archives. Quiescence is highly regulated to preserve stem cell function. The stem cells portal is a shared platform for the stem cells and stem cells translational medicine sister journals, providing uptotheminute coverage of the latest research from bench science and developments to clinical applications.
Mar 12, 2020 cardiopoietic stem cells have reached advanced clinical testing for ischemic heart failure. Adult lung spheroid cells contain progenitor cells and. The journal of stem cells and regenerative medicine jsrm, an official organ of the german society for stem cell research gsz is an open access online journal covering areas of basic research, translational work and clinical studies in the specialty of stem cells and regenerative medicine including allied specialities such as biomaterials and nano technology relevant to the core subject. The journal publishes basic, translational, and clinical research, including animal models and clinical trials. Stem cell research and medicine mainly focuses on the basic research, clinical studies and translational research in the fields of stem cell biology and regenerative medicine. Cell stem cell impact factor, if, number of article, detailed information and journal factor. Mesenchymal stem cell therapy targeting mitochondrial. One of the worlds leading journals in the field of translational research, journal of translational medicine is dedicated to turning fundamental discoveries. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, stem cells translational medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. Targeting senescent cells in translational medicine embo. By bridging stem cell research and helping speed translations of emerging lab discoveries into clinical trials, stem cells translational medicine will help move applications of these critical investigations closer to accepted best practices and ultimately improve patient. Stem cells translational medicine scimago journal rank. Used as drugs, stem cells are required to follow the regulatory pathway of pharmaceuticals into the clinic. Stem cells translational medicine works to advance the clinical utilization of stem cell molecular and cellular biology.
Jan 15, 2019 pancreatic cancer is one of the leading causes of cancerrelated death in the united states and survival outcomes remain dismal despite significant advances in molecular diagnostics and therapeutics in clinical practice. Stem cells scs research is one of the most promising approaches to regenerative medicine. Stem cell research is dedicated to publishing highquality manuscripts focusing on the. Measuring the efficiency of vector integration into the t cell genome is important for assessing the potency and safety of these cancer immunotherapies. The aim of this openlabel phase i clinical trial was to evaluate the safety of two repeated intrathecal injections of autologous bone marrow bmderived mesenchymal stromal cells mscs in als patients. Cancer recurrence is the important problem of cholangiocarcinoma cca patients, lead to a very high mortality rate. Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells mscs, either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic. Articles from stem cells translational medicine are provided here courtesy of wileyblackwell. Interestingly, pools of cells enriched in senescent cells from centenarians were reprogrammed in vitro to pluripotent stem cells.
Stem cells translational medicine impact factor if 2019. Pseudouridylation of trnaderived fragments steers translational control in stem cells previous article cryoem structure of human dicer and its complexes with a premirna substrate next article embryogenesis and adult life in the absence of intrinsic apoptosis effectors bax, bak, and bok. The ability to grow organoids from patientderived healthy and diseased tissue allows for the study of organ development, tissue. Stem cells translational medicine rg journal impact. A digital droplet polymerase chain reaction ddpcr assay was developed and evaluated for assessing the average number of lenti and retroviral vectors. Stem cells rg journal impact rankings 2018 and 2019. By bridging stem cell research and helping speed translations of emerging lab discoveries into clinical trials, the journal helps move applications of these critical. Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells. Cancer translational medicine is especially interested in cancer risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and experimental therapeutics in the field of chemotherapy, radiotherapy and biotherapy immunetherapy, genetherapy, targettherapy, stem cell therapy and so on. Stem cells translational medicine is the official scientific journal of the cord blood association. March 12, 2020 in a new study released today in stem cells translational medicine sctm, researchers at the university of california, davis and the chinese academy of science demonstrate how induced pluripotent stem cells can provide a renewable supply of endothelial cells. Cell stem cell impact factor if 201920182017 bioxbio. Genetically engineered t cells have become an important therapy for b cell malignancies.
Cytomegalovirus infection induces a stem cell phenotype in. In a seminal study, in vivo reprogramming of somatic cells was shown to restore their proliferative potential abad et al, 20, a relevant approach for future applications in tissue repair and regenerative medicine. The team found that cd3 was an important factor in helping. Adult lung spheroid cells contain progenitor cells and mediate regeneration in rodents with bleomycininduced pulmonary fibrosis. Therefore, the identification of candidate markers to predict cca recurrence is needed in order to effectively manage the disease.
World journal of stem cells baishideng publishing group. Translational regenerative medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. Mesenchymal stromal cells mscs have attracted intense interest due to their powerful intrinsic properties of selfregeneration, immunomodulation and multipotency, as well as being readily available and easy to isolate and culture. Advances in stem cell research, 18 november 2015, a virtual conference pluripotent stem cells. Notwithstanding, msc based therapy suffers reduced efficacy due to several challenges which include unfavorable microenvironmental factors in vitro and in vivo. Mesenchymal stem cells mscs are emerging as a promising therapeutic. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce adverse prognosis, such as metastasis. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work. Year, bioxbio journal impact, if, total articles, total cites. Current research in translational medicine editorial board. In this issue regenerative abilities of mesenchymal stem cells via acting as an ideal vehicle for subcellular component delivery in acute kidney injury mitochondrial biogenesis.